胡博淳,男,工学博士,1992年1月生于河南省许昌市。主要从事酶工程及绿色有机合成等领域研究。
邮箱:hbcwstc@126.com
学习/工作经历:
2010.09至2014.06 河南大学 生物工程专业 (学士)
2014.09至2017.06 江南大学 制药工程专业,药物化学方向 (硕士)
2017.09至2021.06 江南大学 发酵工程专业,生物化学与分子生物学方向 (博士)
2021.09至今 许昌学院 食品与药学院,讲师
主要研究方向:
1)酶的克隆表达及其构效关系解析;
2)酶分子改造及其催化应用;
3)手性药物中间体合成的生物催化工艺开发
主持/参与的科研项目:
1)江苏省研究生科研与实践创新计划:KYCX19_1840,2019.05至2021.03,主持,结题
2)国家自然科学基金面上项目: 21772068, 2018.01至2021.12,参与,在研
代表性研究论文:
1)Bochun Hu, Die Hu, et al. Manipulating the regioselectivity of a Solanum lycopersicum epoxide hydrolase for the enantioconvergent synthesis of enantiopure alkane- and alkene-1,2-diols. Catalysis Science & Technology, 2020, 10, 5886-5895. (中科院二区,IF=6.1);
2)Bochun Hu, Die Hu, et al. Near-perfect kinetic resolution of racemic p-chlorostyrene oxide by SlEH1, a novel epoxide hydrolase from Solanum lycopersicum with extremely high enantioselectivity. International Journal of Biological Macromolecules, 2020, 147, 1213-1220. (中科院二区,IF=6.9);
3)Bochun Hu, Chuang Li, et al. Improvement in the activity and enantioconvergency of PvEH3, an epoxide hydrolase from Phaseolus vulgaris, for p-chlorostyrene oxide by site-saturation. Catalysis Communications, 2018, 117, 9-13. (中科院三区,IF=3.7);
4)Die Hu, Bochun Hu(共同一作), et al. Nearly perfect kinetic resolution of racemic o-nitrostyrene oxide by AuEH2, a microsomal epoxide hydrolase from Aspergillus usamii, with high enantio- and regio-selectivity. International Journal of Biological Macromolecules, 2021, 169, 1–7. (中科院二区,IF=6.9);
5)Zheng Wen, Bochun Hu(共同一作), et al. Efficient kinetic resolution of para-chlorostyrene oxide at elevated concentration by Solanum lycopersicum epoxide hydrolase in the presence of Tween-20. Catalysis Communications, 2021, 149, 106180. (中科院三区,IF=3.6);
6)Lijun Song, Bochun Hu(共同一作), et al. Decoquinate derivatives: a new class of potent antischistosomal agents against Schistosoma japonicumin. Chinese Chemical Letters, 2017, 28, 1547-1552. (中科院二区,IF=4.6)
已授权发明专利:
1)邬敏辰,胡博淳,等,专利号:2018100338798,一种催化活性和对映归一性提高的PvEH3突变体;
2)邬敏辰,张婷,胡博淳,等,专利号:201811621705X,一种催化效率提高的木聚糖酶突变体